MAbsorbents® were developed to mimic the Phe-132, Tyr-133 dipeptide binding site in the hydrophobic core structure of Protein A. We have developed IgG binding ligand libraries using a triazine scaffold substituted with aromatic amines. The resultant synthetic bifunctional ligands exhibit high affinities for human immunoglobulin G. Hence, MAbsorbent® A1P and A2P provide excellent purification performance.
MAbsorbents® effectively bind a wide variety of human and mammalian polyclonal antibodies (including bovine, mouse, sheep, goat, horse and rabbit) as well as whole monoclonal antibodies, humanized antibody chimeras and antibody fragments. MAbsorbent® A2P P6HF in particular is normally recommended for human or humanized antibodies, while MAbsorbent® A1P has proven ideal for murine antibodies.
Binding Characteristics of Mabsorbents:
- Polyclonal IgG and all sub-classes
- Monoclonal antibodies(all classes of IgG)
- Humanized antibodies
- Antibody fragments
- Antibody fusion proteins
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